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CAS No.: 476-66-4

鞣花酸 Catalog No. CSN10902

Synonyms: Elagostasine;Gallogen;Lagistase

Ellagic acid is a potent and cell permeable casein kinase 2 (CK2) inhibitor with Ki of 20 nM, acts as a potent antioxidant and anti-mutagenic.

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Casein Kinase 2

Ki:20nM
描述Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive CK2 (Casein kinase 2) inhibitor, with an IC50 of 40 nM and a Ki of 20 nM^[3]. Ellagic acid (EA; 10 mg/kg/day; p.o., 14 days) strongly decreases MDA brain content by 17%, and reduces the levels of brain TNF-α by 42% in rats. Ellagic acid markedly increases the reduced brain contents of 5-HT (39%), dopamine (DA, 71%), and norepinephrine (NE, 77%). Ellagic acid (10 mg/kg, p.o., 14 days) causes decreased histopathological changes induced by Doxorubicin in rats^[4]. Ellagic acid (10 μM) exhibits cytotoxic effects on MCF-7 cells after treatment of radiation. Ellagic acid (10 μM) in combination with Irradiation (IR) significantly abridges the capacity of MCF-7 cells to form colonies equated with individual treatments. Ellagic acid with IR also induces cell apoptosis, and facilitates the upregulation of pro-apopttotic Bax and downregulation of Bcl-2 in MCF-7 cells^[5]. The antitumor activity of EA has been mostly attributed to direct antiproliferative and apoptotic effects. Moreover, EA can inhibit tumour cell migration, extra-cellular matrix invasion and angiogenesis^[6].
临床研究

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NCT00788866	Intrauterine Growth Restrictio... more >>n Collapse <<	Not Applicable	Completed	-	United States, Missouri ... more >> St Louis Children's Hospital St Louis, Missouri, United States, 63110 Collapse <<
NCT02333461	Overweight Ob... more >>esity Collapse <<	Not Applicable	Completed	-	-
NCT03140280	Myelodysplastic Syndromes	Phase 2	Recruiting	April 1, 2020	United States, Wisconsin ... more >> Froedtert & the Medical College of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Ehab Atallah, MD 414-805-4600 eatallah@mcw.edu Contact: Medical College of Wisconsin Cancer Center Clinical Trials Office 414-805-8900 cccto@mcw.edu Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.3091 mL
- 16.5457 mL
- 33.0915 mL
- 5 mM
- 0.6618 mL
- 3.3091 mL
- 6.6183 mL
- 10 mM
- 0.3309 mL
- 1.6546 mL
- 3.3091 mL

技术信息

CAS号

476-66-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H6O8

运输

蓝冰

分子量

302.19

别名

Elagostasine;Gallogen;Lagistase;Ellagic Acid;TBBD;Alizarine Yellow;Benzoaric acid;CCRIS-774;HSDB-7574;鞣花酸

溶解度

DMSO	3.0 mg/mL (9.9 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00788866	Intrauterine Growth Restrictio... more >>n Collapse <<	Not Applicable	Completed	-	United States, Missouri ... more >> St Louis Children's Hospital St Louis, Missouri, United States, 63110 Collapse <<
NCT02333461	Overweight Ob... more >>esity Collapse <<	Not Applicable	Completed	-	-
NCT03140280	Myelodysplastic Syndromes	Phase 2	Recruiting	April 1, 2020	United States, Wisconsin ... more >> Froedtert & the Medical College of Wisconsin Recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Ehab Atallah, MD 414-805-4600 eatallah@mcw.edu Contact: Medical College of Wisconsin Cancer Center Clinical Trials Office 414-805-8900 cccto@mcw.edu Collapse <<
NCT02935777	Mental Processes	Phase 1	Completed	-	United Kingdom ... more >> Queen Margaret University Edinburgh, Scotland, United Kingdom, EH21 6UU Collapse <<
NCT03482401	Breast Cancer	Not Applicable	Active, not recruiting	June 1, 2019	Spain ... more >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 Collapse <<
NCT00455416	Follicular Lymphoma	Phase 2	Unknown	December 2009	Norway ... more >> RRHF RIkshospitalet Radiumhospitalet HF Recruiting Montebello, Oslo, Norway, 0310 Contact: Kjell Magne Russnes, MD +4722934000 k.m.russnes@medisin.uio.no Contact: Harald JR Holte, MD, PhD +4722934000 harald.holte@radiumhospitalet.no Principal Investigator: Harald Jr Holte, Md, PhD Sub-Investigator: Kjell Magne Russnes, MD Collapse <<
NCT03535675	Adenocarcinoma of the Prostate	Phase 3	Recruiting	December 2021	United States, District of Col... more >>umbia Sibley Memorial Hospital Recruiting Washington, District of Columbia, United States, 20016 Contact: Channing Paller, MD 202-660-6500 cpaller1@jhmi.edu United States, Maryland Johns Hopkins Hospital Recruiting Baltimore, Maryland, United States, 21205 Contact: Donna Dowling, RN 410-614-9526 ddowlin1@jhmi.edu Principal Investigator: Channing Paller, MD Collapse <<
NCT01961869	Healthy Volunteers	Phase 1	Active, not recruiting	December 2019	United States, Ohio ... more >> Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio, United States, 43210 Collapse <<
NCT01249469	Solar Lentigines	Not Applicable	Unknown	June 2011	Taiwan ... more >> National Taiwan University Hospital Recruiting Taipei, Taiwan, 100 Contact: Yi-Hua Liao, MD, PhD 886-2-23562141 yihualiao@ntu.edu.tw Principal Investigator: Yi-Hua Liao, MD, PhD Collapse <<
NCT03318042	Genotype, Metabotype and Dieta... more >>ry Habits Collapse <<	Not Applicable	Completed	-	Spain ... more >> Cebas-Csic Murcia, Spain, 30100 Collapse <<
NCT01916239	Colorectal Cancer	Phase 1 Phase 2	Completed	-	Spain ... more >> Hospital General Universitario Reina Sofía Murcia, Spain, 30003 Collapse <<
NCT01705093	Childhood Obesity ... more >> Cardiovascular Disease Collapse <<	Phase 2	Completed	-	United States, California ... more >> Ragle Human Nutrition Research Center, Academic Surge, UC Davis Davis, California, United States, 95616 Collapse <<
NCT03548701	-	-	Recruiting	May 21, 2020	United States, New York ... more >> Mount Sinai Hospital Recruiting New York, New York, United States, 10029 Contact: Patrick Maher, MD 404-550-9559 patrick.maher@mountsinai.org Contact: Daniel Katz, MD 732-322-6675 daniel.katz@mountsinai.org Principal Investigator: Patrick Maher, MD Collapse <<
NCT02056496	Healthy	Phase 1	Completed	-	Spain ... more >> UCAM (San Antonio Catholic University from Murcia) Murcia, Spain, 30107 Collapse <<
NCT02263378	HPV Infection	Not Applicable	Completed	-	-
NCT03713164	Healthy	Phase 1 Phase 2	Completed	-	United States, California ... more >> UCLA Center for Human Nutrition, 900 Veteran Ave. Los Angeles, California, United States, 90095 Collapse <<
NCT02370641	Urolith	Not Applicable	Completed	-	-

鞣花酸 Catalog No. CSN10902

靶点选择性

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